PRENATAL STRESS DOWN-REGULATES REELIN EXPRESSION BY METHYLATION OF ITS PROMOTER AND INDUCES ADULT BEHAVIORAL IMPAIRMENTS IN RATS.

Prenatal stress down-regulates Reelin expression by methylation of its promoter and induces adult behavioral impairments in rats.

Prenatal stress causes predisposition to cognitive and emotional disturbances and is a risk factor towards the development of neuropsychiatric conditions like depression, bipolar disorders and schizophrenia.The extracellular protein Reelin, expressed by Cajal-Retzius cells during cortical development, plays critical roles on cortical lamination and

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DISC-3D: dual-hydrogel system enhances optical imaging and enables correlative mass spectrometry imaging of invading multicellular tumor spheroids

Abstract Multicellular tumor spheroids embedded in collagen I matrices are common in vitro systems for the study of solid tumors that reflect the physiological environment and complexities of the in vivo environment.While collagen I environments are physiologically relevant and permissive of cell invasion, studying spheroids in such hydrogels prese

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Surgical resection of glioma involving eloquent brain areas: Tumor boundary, functional boundary, and plasticity consideration

Glioma is the most refractory intracranial tumor, and its diffuse infiltrative growth characteristics make total resection impossible graco ascent in a biological sense, especially when tumors invade eloquent brain areas.Thus, identifying the equilibrium between tumor resection and functional preservation remains a challenge in glioma surgery.The a

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miR-3529-3p/ABCA1 axis regulates smooth muscle cell homeostasis by enhancing inflammation via JAK2/STAT3 pathway

BackgroundThoracic Aortic Dissection (TAD) is a life-threatening disease without effective drug treatments.The disruption of HASMCs homeostasis is one direct histopathologic alteration in TAD pathological process.Several miRNAs have been shown abnormally expressed in TAD and to regulate HASMCs homeostasis.The primary goal of this study is to identi

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Pemotong Tempurung Kelapa Gergaji Ganda

ABSTRAKKeanekaragaman produk kerajinan tempurung kelapa menuntut diciptakannya peralatan-peralatan khusus untuk proses produksinya.Penggunaan pemotong gergaji tunggal untuk membuat bahan baku tas tempurung kelapa berbentuk bujur sangkar dirasakan masih kurang optimal.Satu kali proses potong hanya mampu menghasilkan satu sisi pemotongan.Tujuan penel

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